4nn5

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Revision as of 00:11, 5 August 2016

Cytokine receptor complex - Crystal form 1A

Structural highlights

4nn5 is a 3 chain structure with sequence from Lk3 transgenic mice. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	4nn6, 4nn7
Gene:	Tslp (LK3 transgenic mice), Il7r, IL7RA (LK3 transgenic mice), Crlf2, CRLF2 (TSLPR), Crlm2, Tpte2, Tslpr (LK3 transgenic mice)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TSLP_MOUSE] Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity). [CRLF2_MOUSE] Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. [IL7RA_MOUSE] Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

Publication Abstract from PubMed

Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediated signaling complex reveals how TSLP establishes extensive interfaces with its cognate receptor (TSLPR) and the shared interleukin 7 receptor alpha-chain (IL-7Ralpha) to evoke membrane-proximal receptor-receptor contacts poised for intracellular signaling. Binding of TSLP to TSLPR is a mechanistic prerequisite for recruitment of IL-7Ralpha to the high-affinity ternary complex, which we propose is coupled to a structural switch in TSLP at the crossroads of the cytokine-receptor interfaces. Functional interrogation of TSLP-receptor interfaces points to putative interaction hotspots that could be exploited for antagonist design. Finally, we derive the structural rationale for the functional duality of IL-7Ralpha and establish a consensus for the geometry of ternary complexes mediated by interleukin 2 (IL-2)-family cytokines.

Structural basis of the proinflammatory signaling complex mediated by TSLP.,Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN Nat Struct Mol Biol. 2014 Mar 16. doi: 10.1038/nsmb.2794. PMID:24632570^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Verstraete K, van Schie L, Vyncke L, Bloch Y, Tavernier J, Pauwels E, Peelman F, Savvides SN. Structural basis of the proinflammatory signaling complex mediated by TSLP. Nat Struct Mol Biol. 2014 Mar 16. doi: 10.1038/nsmb.2794. PMID:24632570 doi:http://dx.doi.org/10.1038/nsmb.2794

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4nn5"

@@ Line 1: / Line 1: @@
 ==Cytokine receptor complex - Crystal form 1A==
 <StructureSection load='4nn5' size='340' side='right' caption='[[4nn5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4nn6|4nn6]], [[4nn7|4nn7]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tslp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Il7r, IL7RA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Crlf2, CRLF2 (TSLPR), Crlm2, Tpte2, Tslpr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nn5 RCSB], [http://www.ebi.ac.uk/pdbsum/4nn5 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn5 OCA], [http://pdbe.org/4nn5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nn5 RCSB], [http://www.ebi.ac.uk/pdbsum/4nn5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nn5 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 18: / Line 19: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4nn5" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Interleukin receptor|Interleukin receptor]]
 == References ==
 <references/>

4nn5

From Proteopedia

Revision as of 00:11, 5 August 2016

Cytokine receptor complex - Crystal form 1A

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

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