4p58

From Proteopedia

(Difference between revisions)

Revision as of 00:49, 5 August 2016

Crystal structure of mouse comt bound to an inhibitor

Structural highlights

4p58 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Activity:	Catechol O-methyltransferase, with EC number 2.1.1.6
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[COMT_MOUSE] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.

Publication Abstract from PubMed

Catechol O-methyl transferase belongs to the diverse family of S-adenosyl-l-methionine transferases. It is a target involved in the treatment of Parkinson's disease. Here we present a fragment-based screening approach to discover noncatechol derived COMT inhibitors which bind at the SAM binding pocket. We describe the identification and characterization of a series of highly ligand efficient SAM competitive bisaryl fragments (LE = 0.33-0.58). We also present the first SAM-competitive small-molecule COMT co-complex crystal structure.

A Fragment-Based Approach to Identifying S-Adenosyl-l-methionine -Competitive Inhibitors of Catechol O-Methyl Transferase (COMT).,Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R, Matsumoto SI, Mizukami A, Okubo S, Okada K, Saikatendu K, Walsh L, Wu H, Hixon MS J Med Chem. 2014 Jun 4. PMID:24847974^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Lanier M, Ambrus G, Cole DC, Davenport R, Ellery J, Fosbeary R, Jennings AJ, Kadotani A, Kamada Y, Kamran R, Matsumoto SI, Mizukami A, Okubo S, Okada K, Saikatendu K, Walsh L, Wu H, Hixon MS. A Fragment-Based Approach to Identifying S-Adenosyl-l-methionine -Competitive Inhibitors of Catechol O-Methyl Transferase (COMT). J Med Chem. 2014 Jun 4. PMID:24847974 doi:http://dx.doi.org/10.1021/jm500475k

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4p58"

Categories: Catechol O-methyltransferase | Lanier, M | Sam binding site

@@ Line 1: / Line 1: @@
 ==Crystal structure of mouse comt bound to an inhibitor==
 <StructureSection load='4p58' size='340' side='right' caption='[[4p58]], [[Resolution|resolution]] 2.06&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2F6:1,3-DIMETHYL-1H,1H-3,4-BIPYRAZOLE'>2F6</scene></td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Catechol_O-methyltransferase Catechol O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.6 2.1.1.6] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p58 RCSB], [http://www.ebi.ac.uk/pdbsum/4p58 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p58 OCA], [http://pdbe.org/4p58 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4p58 RCSB], [http://www.ebi.ac.uk/pdbsum/4p58 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4p58 ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4p58" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Catechol O-methyltransferase|Catechol O-methyltransferase]]
 == References ==
 <references/>

4p58

From Proteopedia

Revision as of 00:49, 5 August 2016

Crystal structure of mouse comt bound to an inhibitor

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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