1lof
From Proteopedia
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|PDB= 1lof |SIZE=350|CAPTION= <scene name='initialview01'>1lof</scene>, resolution 2.3Å | |PDB= 1lof |SIZE=350|CAPTION= <scene name='initialview01'>1lof</scene>, resolution 2.3Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lof OCA], [http://www.ebi.ac.uk/pdbsum/1lof PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lof RCSB]</span> | ||
}} | }} | ||
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[[Category: Bourne, Y.]] | [[Category: Bourne, Y.]] | ||
[[Category: Cambillau, C.]] | [[Category: Cambillau, C.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: GAL]] | ||
| - | [[Category: MN]] | ||
[[Category: lectin]] | [[Category: lectin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:05:16 2008'' |
Revision as of 19:05, 30 March 2008
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| , resolution 2.3Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-RAY STRUCTURE OF A BIANTENNARY OCTASACCHARIDE-LECTIN COMPLEX AT 2.3 ANGSTROMS RESOLUTION
Overview
The structure and flexibility of saccharides have a profound and specific influence in several biological processes such as protein protection and the maintenance of conformational integrity, and in recognition events involving viruses, enzymes, and lectins. To establish the structural bases of these phenomena, we describe herein the extensively refined 2.3-A resolution x-ray structure of a biantennary octasaccharide of the N-acetyllactosamine type, complexed to isolectin I from Lathyrus ochrus. The two octasaccharides are located in clefts at each end of the long axis of the lectin. The conformations of both the lectin and the saccharide are slightly modified upon binding. The complex is stabilized by numerous hydrogen bonds, many of them involving water molecules. It is also stabilized by van der Waals interactions, including some with aromatic residues. A more general model of a possible lectin-glycoprotein interaction is also proposed.
About this Structure
1LOF is a Protein complex structure of sequences from Lathyrus ochrus. Full crystallographic information is available from OCA.
Reference
X-ray structure of a biantennary octasaccharide-lectin complex refined at 2.3-A resolution., Bourne Y, Rouge P, Cambillau C, J Biol Chem. 1992 Jan 5;267(1):197-203. PMID:1730588
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