This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3fb2
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | ==Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.== | ||
<StructureSection load='3fb2' size='340' side='right' caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3fb2' size='340' side='right' caption='[[3fb2]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3fb2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FB2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FB2 FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u5p|1u5p]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u5p|1u5p]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPTA2, SPTAN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [http://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fb2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fb2 OCA], [http://pdbe.org/3fb2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fb2 RCSB], [http://www.ebi.ac.uk/pdbsum/3fb2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fb2 ProSAT], [http://www.topsan.org/Proteins/NESGC/3fb2 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN]] West syndrome. The disease is caused by mutations affecting the gene represented in this entry. |
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/SPTN1_HUMAN SPTN1_HUMAN]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. |
==See Also== | ==See Also== | ||
*[[Spectrin|Spectrin]] | *[[Spectrin|Spectrin]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Acton, T B]] | [[Category: Acton, T B]] | ||
[[Category: Ciccosanti, C]] | [[Category: Ciccosanti, C]] | ||
Revision as of 01:40, 5 August 2016
Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.
| |||||||||||
Categories: Human | Acton, T B | Ciccosanti, C | Foote, E L | Hunt, J F | Janjua, H | Montelione, G T | Structural genomic | Seetharaman, J | Shastry, R | Su, M | Tong, L | Vorobiev, S M | Xiao, R | Actin capping | Actin-binding | Brain spectrin | Calmodulin-binding | Cytoskeleton | Fordrin alpha chain | Hr5563a | Nesg | Non-erythroid alpha chain alpha-ii spectrin | Phosphoprotein | PSI, Protein structure initiative | Sh3 domain | Spectrin alpha chain | Spta2 human | Sptan1 | Structural protein
