1lri
From Proteopedia
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|PDB= 1lri |SIZE=350|CAPTION= <scene name='initialview01'>1lri</scene>, resolution 1.45Å | |PDB= 1lri |SIZE=350|CAPTION= <scene name='initialview01'>1lri</scene>, resolution 1.45Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1beo|1BEO]], [[1bxm|1BXM]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lri FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lri OCA], [http://www.ebi.ac.uk/pdbsum/1lri PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lri RCSB]</span> | ||
}} | }} | ||
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[[Category: Prange, T.]] | [[Category: Prange, T.]] | ||
[[Category: Venard, P.]] | [[Category: Venard, P.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: CLR]] | ||
[[Category: cholesterol]] | [[Category: cholesterol]] | ||
[[Category: cryptogein]] | [[Category: cryptogein]] | ||
[[Category: sterol carrier protein]] | [[Category: sterol carrier protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:06:26 2008'' |
Revision as of 19:06, 30 March 2008
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| , resolution 1.45Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Related: | 1BEO, 1BXM
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
BETA-CRYPTOGEIN-CHOLESTEROL COMPLEX
Overview
Cryptogein is a small 10 kDa elicitor produced by the phytoparasitic oomycete Phytophthora cryptogea. The protein also displays a sterol carrier activity. The native protein crystallizes in space group P4(1)22, with unit-cell parameters a = b = 46.51, c = 134.9 A (diffraction limit: 2.1 A). Its complex with cholesterol crystallizes in space group C222(1), with unit-cell parameters a = 30.96, b = 94.8, c = 65.3 A and a resolution enhanced to 1.45 A. The large inner non-specific hydrophobic cavity is able to accommodate a large variety of 3-beta-hydroxy sterols. Cryptogein probably acts as a sterol shuttle helping the pathogen to grow and complete its life cycle.
About this Structure
1LRI is a Single protein structure of sequence from Phytophthora cryptogea. Full crystallographic information is available from OCA.
Reference
The 1.45 A resolution structure of the cryptogein-cholesterol complex: a close-up view of a sterol carrier protein (SCP) active site., Lascombe MB, Ponchet M, Venard P, Milat ML, Blein JP, Prange T, Acta Crystallogr D Biol Crystallogr. 2002 Sep;58(Pt 9):1442-7. Epub 2002, Aug 23. PMID:12198300
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