1lv9
From Proteopedia
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|PDB= 1lv9 |SIZE=350|CAPTION= <scene name='initialview01'>1lv9</scene> | |PDB= 1lv9 |SIZE=350|CAPTION= <scene name='initialview01'>1lv9</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lv9 OCA], [http://www.ebi.ac.uk/pdbsum/1lv9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1lv9 RCSB]</span> | ||
}} | }} | ||
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[[Category: chemokine]] | [[Category: chemokine]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:07:49 2008'' |
Revision as of 19:07, 30 March 2008
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CXCR3 Binding Chemokine IP-10/CXCL10
Overview
The structure of IP-10 was solved by NMR spectroscopy and represents the first structure from the class of agonists toward the receptor CXCR3. CXCR3 binding chemokines are unique in their ability to bind receptors from both the CC and CXC classes of chemokine receptors. An unusual structural feature of IP-10 was identified that may provide the basis for the ability of IP-10 to bind both CXCR3 and CCR3. The surface of IP-10 that interacts with the N-terminus of CXCR3 was defined by monitoring changes in the NMR spectrum of IP-10 upon addition of a CXCR3 N-terminal peptide. These studies indicated that the interaction involves a hydrophobic cleft, formed by the N-loop and 40s-loop region of IP-10, similar to the interaction surface observed for other chemokines such as IL-8. An additional region of interaction was observed that consists of a hydrophobic cleft formed by the N-terminus of IP-10 and 30s-loop of IP-10.
About this Structure
1LV9 is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions., Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD, Biochemistry. 2002 Aug 20;41(33):10418-25. PMID:12173928
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