4gnt
From Proteopedia
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==Complex of ChREBP and 14-3-3beta== | ==Complex of ChREBP and 14-3-3beta== | ||
<StructureSection load='4gnt' size='340' side='right' caption='[[4gnt]], [[Resolution|resolution]] 2.41Å' scene=''> | <StructureSection load='4gnt' size='340' side='right' caption='[[4gnt]], [[Resolution|resolution]] 2.41Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4gnt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4gnt]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GNT FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ywhab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ywhab ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gnt RCSB], [http://www.ebi.ac.uk/pdbsum/4gnt PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gnt OCA], [http://pdbe.org/4gnt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gnt RCSB], [http://www.ebi.ac.uk/pdbsum/4gnt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gnt ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/MLXPL_MOUSE MLXPL_MOUSE]] Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. | + | [[http://www.uniprot.org/uniprot/1433B_MOUSE 1433B_MOUSE]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2 (By similarity). [[http://www.uniprot.org/uniprot/MLXPL_MOUSE MLXPL_MOUSE]] Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Lk3 transgenic mice]] |
[[Category: Huang, N]] | [[Category: Huang, N]] | ||
[[Category: Zhang, H]] | [[Category: Zhang, H]] | ||
Revision as of 04:29, 5 August 2016
Complex of ChREBP and 14-3-3beta
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