3kg4

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==Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens==
==Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens==
<StructureSection load='3kg4' size='340' side='right' caption='[[3kg4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='3kg4' size='340' side='right' caption='[[3kg4]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mannheimia_succiniciproducens Mannheimia succiniciproducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KG4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mansm Mansm]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KG4 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MS0988 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=157673 Mannheimia succiniciproducens])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MS0988 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=221988 MANSM])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3kg4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kg4 OCA], [http://pdbe.org/3kg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3kg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kg4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q65TW5_MANSM Q65TW5_MANSM]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) (By similarity).
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[[http://www.uniprot.org/uniprot/CAS5_MANSM CAS5_MANSM]] CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). This protein is a sequence-specific endonuclease that cleaves pre-crRNA at G21 into mature crRNA. Does not cleave pre-crRNA associated with the T.thermophilus strain HB27 Cas5 protein (AC Q746C2) CRISPR locus (PubMed:23006625). The reaction mechanism may proceed by an intramolecular attack of the 2'-hydoxyl group of G21 on the scissile phosphodiester, cutting the precursor 3' to G21 residue yielding 5'-hydroxyl and 2' and/or 3' ends lacking a hydroxyl group (perhaps a 2'/3' cyclic phosphodiester) (Ref.2).<ref>PMID:23006625</ref> <ref>PMID:23006625</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kg4 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Mannheimia succiniciproducens]]
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[[Category: Mansm]]
[[Category: Almo, S C]]
[[Category: Almo, S C]]
[[Category: Bain, K T]]
[[Category: Bain, K T]]

Revision as of 05:37, 5 August 2016

Crystal structure of an uncharacterized protein from Mannheimia succiniciproducens

3kg4, resolution 1.95Å

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