1m0g
From Proteopedia
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|PDB= 1m0g |SIZE=350|CAPTION= <scene name='initialview01'>1m0g</scene> | |PDB= 1m0g |SIZE=350|CAPTION= <scene name='initialview01'>1m0g</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CD:CADMIUM ION'>CD</scene> | + | |LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1m0j|1M0J]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m0g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m0g OCA], [http://www.ebi.ac.uk/pdbsum/1m0g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m0g RCSB]</span> | ||
}} | }} | ||
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[[Category: Spadaccini, R.]] | [[Category: Spadaccini, R.]] | ||
[[Category: Temussi, P A.]] | [[Category: Temussi, P A.]] | ||
| - | [[Category: CD]] | ||
[[Category: cadmium-thiolate cluster]] | [[Category: cadmium-thiolate cluster]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:09:40 2008'' |
Revision as of 19:09, 30 March 2008
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| Ligands: | |||||||
| Related: | 1M0J
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the alpha domain of mt_nc
Overview
The structure of [113Cd(7)]-metallothionein (MT_nc) of the Antarctic fish Notothenia coriiceps, the first three-dimensional structure of a fish metallothionein, was determined by homonuclear 1H NMR experiments and heteronuclear [1H, 113Cd]-correlation spectroscopy. MT_nc is composed of an N-terminal beta domain with 9 cysteines and 3 metal ions and a carboxy-terminal alpha-domain with 11 cysteines and 4 metal ions. The position of the ninth Cys of the alpha domain of MT_nc is different from the corresponding Cys of mammalian MTs. As a result, the last CXCC motif in the mammalian MT sequence becomes CXXXCC in the fish MT. This difference leads to a structural change of the alpha domain and, in turn, to a different charge distribution with respect to that observed in mammalian metallothioneins.
About this Structure
1M0G is a Single protein structure of sequence from Notothenia coriiceps. Full crystallographic information is available from OCA.
Reference
Solution structure of MT_nc, a novel metallothionein from the Antarctic fish Notothenia coriiceps., Capasso C, Carginale V, Crescenzi O, Di Maro D, Parisi E, Spadaccini R, Temussi PA, Structure. 2003 Apr;11(4):435-43. PMID:12679021
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