3roc

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==Crystal structure of human p38 alpha complexed with a pyrimidinone compound==
==Crystal structure of human p38 alpha complexed with a pyrimidinone compound==
<StructureSection load='3roc' size='340' side='right' caption='[[3roc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
<StructureSection load='3roc' size='340' side='right' caption='[[3roc]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3roc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ROC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3roc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ROC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ROC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=29A:3-{5-CHLORO-4-[(2,4-DIFLUOROBENZYL)OXY]-6-OXOPYRIMIDIN-1(6H)-YL}-N-(2-HYDROXYETHYL)-4-METHYLBENZAMIDE'>29A</scene>, <scene name='pdbligand=29B:4-[4-(4-FLUOROPHENYL)-1H-PYRAZOL-3-YL]PYRIDINE'>29B</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=29A:3-{5-CHLORO-4-[(2,4-DIFLUOROBENZYL)OXY]-6-OXOPYRIMIDIN-1(6H)-YL}-N-(2-HYDROXYETHYL)-4-METHYLBENZAMIDE'>29A</scene>, <scene name='pdbligand=29B:4-[4-(4-FLUOROPHENYL)-1H-PYRAZOL-3-YL]PYRIDINE'>29B</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, THP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, THP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase Mitogen-activated protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.24 2.7.11.24] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3roc RCSB], [http://www.ebi.ac.uk/pdbsum/3roc PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3roc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3roc OCA], [http://pdbe.org/3roc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3roc RCSB], [http://www.ebi.ac.uk/pdbsum/3roc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3roc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3roc" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Mitogen-activated protein kinase]]
[[Category: Shieh, H S]]
[[Category: Shieh, H S]]

Revision as of 06:02, 5 August 2016

Crystal structure of human p38 alpha complexed with a pyrimidinone compound

3roc, resolution 1.70Å

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