1m24
From Proteopedia
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|PDB= 1m24 |SIZE=350|CAPTION= <scene name='initialview01'>1m24</scene>, resolution 0.90Å | |PDB= 1m24 |SIZE=350|CAPTION= <scene name='initialview01'>1m24</scene>, resolution 0.90Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene> | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=VOL:L-VALINOL'>VOL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m24 OCA], [http://www.ebi.ac.uk/pdbsum/1m24 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m24 RCSB]</span> | ||
}} | }} | ||
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[[Category: Chugh, J K.]] | [[Category: Chugh, J K.]] | ||
[[Category: Wallace, B A.]] | [[Category: Wallace, B A.]] | ||
| - | [[Category: ACE]] | ||
| - | [[Category: CCN]] | ||
[[Category: antibiotic]] | [[Category: antibiotic]] | ||
[[Category: helical bundle]] | [[Category: helical bundle]] | ||
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[[Category: peptaibol]] | [[Category: peptaibol]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:18 2008'' |
Revision as of 19:10, 30 March 2008
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| , resolution 0.90Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Trichotoxin_A50E, An Ion Channel-Forming Polypeptide
Overview
Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
About this Structure
1M24 is a Protein complex structure of sequences from Trichoderma viride. Full crystallographic information is available from OCA.
Reference
Model for a helical bundle channel based on the high-resolution crystal structure of trichotoxin_A50E., Chugh JK, Bruckner H, Wallace BA, Biochemistry. 2002 Oct 29;41(43):12934-41. PMID:12390019
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