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1m2e
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= kaiA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 Synechococcus elongatus]) | |GENE= kaiA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32046 Synechococcus elongatus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1m2f|1M2F]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2e OCA], [http://www.ebi.ac.uk/pdbsum/1m2e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m2e RCSB]</span> | ||
}} | }} | ||
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[[Category: alpha-beta-alpha sandwich]] | [[Category: alpha-beta-alpha sandwich]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:25 2008'' |
Revision as of 19:10, 30 March 2008
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| Gene: | kaiA (Synechococcus elongatus) | ||||||
| Related: | 1M2F
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Solution structure of the N-terminal domain of Synechococcus elongatus KaiA (KaiA135N); Average minimized structure.
Overview
In the cyanobacterium Synechococcus elongatus (PCC 7942) the proteins KaiA, KaiB, and KaiC are required for circadian clock function. We deduced a circadian clock function for KaiA from a combination of biochemical and structural data. Both KaiA and its isolated carboxyl-terminal domain (KaiA180C) stimulated KaiC autophosphorylation and facilitated attenuation of KaiC autophosphorylation by KaiB. An amino-terminal domain (KaiA135N) had no function in the autophosphorylation assay. NMR structure determination showed that KaiA135N is a pseudo-receiver domain. We propose that this pseudo-receiver is a timing input-device that regulates KaiA stimulation of KaiC autophosphorylation, which in turn is essential for circadian timekeeping.
About this Structure
1M2E is a Single protein structure of sequence from Synechococcus elongatus. Full crystallographic information is available from OCA.
Reference
Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism., Williams SB, Vakonakis I, Golden SS, LiWang AC, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15357-62. Epub 2002 Nov 15. PMID:12438647
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