4fmw
From Proteopedia
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==Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2== | ==Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2== | ||
<StructureSection load='4fmw' size='340' side='right' caption='[[4fmw]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='4fmw' size='340' side='right' caption='[[4fmw]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4fmw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4fmw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4FMW FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RG9MTD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RG9MTD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4fmw RCSB], [http://www.ebi.ac.uk/pdbsum/4fmw PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4fmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fmw OCA], [http://pdbe.org/4fmw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4fmw RCSB], [http://www.ebi.ac.uk/pdbsum/4fmw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4fmw ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN]] Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/TM10A_HUMAN TM10A_HUMAN]] RNA methyltransferase.<ref>PMID:25053765</ref> |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 07:09, 5 August 2016
Crystal structure of methyltransferase domain of human RNA (guanine-9-) methyltransferase domain containing protein 2
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Categories: Human | Arrowsmith, C H | Bountra, C | Dong, A | Edwards, A M | Loppnau, P | Structural genomic | Tempel, W | Weigelt, J | Wu, H | Zeng, H | Guanine | Rna methylation | Rna methyltransferase | Rna modification | Sgc | Transferase
