1m4u
From Proteopedia
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|PDB= 1m4u |SIZE=350|CAPTION= <scene name='initialview01'>1m4u</scene>, resolution 2.42Å | |PDB= 1m4u |SIZE=350|CAPTION= <scene name='initialview01'>1m4u</scene>, resolution 2.42Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= BMP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NOG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= BMP7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), NOG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1bmp|1BMP]], [[3bmp|3BMP]], [[1es7|1ES7]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m4u OCA], [http://www.ebi.ac.uk/pdbsum/1m4u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m4u RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Stapes ankylosis syndrome without symphalangism OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602991 602991]], Symphalangism, proximal OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602991 602991]], Synostoses syndrome, multiple, 1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602991 602991]], Tarsal-carpal coalition syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602991 602991]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: noggin]] | [[Category: noggin]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:11:17 2008'' |
Revision as of 19:11, 30 March 2008
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| , resolution 2.42Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | BMP7 (Homo sapiens), NOG (Homo sapiens) | ||||||
| Related: | 1BMP, 3BMP, 1ES7
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin
Contents |
Overview
The interplay between bone morphogenetic proteins (BMPs) and their antagonists governs developmental and cellular processes as diverse as establishment of the embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. So far, the three-dimensional structures of BMP antagonists and the structural basis for inactivation have remained unknown. Here we report the crystal structure of the antagonist Noggin bound to BMP-7, which shows that Noggin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. The BMP-7-binding affinity of site-specific variants of Noggin is correlated with alterations in bone formation and apoptosis in chick limb development, showing that Noggin functions by sequestering its ligand in an inactive complex. The scaffold of Noggin contains a cystine (the oxidized form of cysteine) knot topology similar to that of BMPs; thus, ligand and antagonist seem to have evolved from a common ancestral gene.
Disease
Known disease associated with this structure: Stapes ankylosis syndrome without symphalangism OMIM:[602991], Symphalangism, proximal OMIM:[602991], Synostoses syndrome, multiple, 1 OMIM:[602991], Tarsal-carpal coalition syndrome OMIM:[602991]
About this Structure
1M4U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin., Groppe J, Greenwald J, Wiater E, Rodriguez-Leon J, Economides AN, Kwiatkowski W, Affolter M, Vale WW, Belmonte JC, Choe S, Nature. 2002 Dec 12;420(6916):636-42. PMID:12478285
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