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3kwn

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==Cathepsin S in complex with Thioether Acetamide P3 inhibitor==
==Cathepsin S in complex with Thioether Acetamide P3 inhibitor==
<StructureSection load='3kwn' size='340' side='right' caption='[[3kwn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3kwn' size='340' side='right' caption='[[3kwn]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KWN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kwn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KWN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KWN FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=23Z:(2R)-1-{5-ACETYL-3-[3-{[2-OXO-2-(1H-PYRROL-1-YL)ETHYL]SULFANYL}-4-(TRIFLUOROMETHYL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL}-3-[4-(1-HYDROXY-1-METHYLETHYL)PIPERIDIN-1-YL]PROPAN-2-OL'>23Z</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=23Z:(2R)-1-{5-ACETYL-3-[3-{[2-OXO-2-(1H-PYRROL-1-YL)ETHYL]SULFANYL}-4-(TRIFLUOROMETHYL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3-C]PYRIDIN-1-YL}-3-[4-(1-HYDROXY-1-METHYLETHYL)PIPERIDIN-1-YL]PROPAN-2-OL'>23Z</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kwn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3kwn RCSB], [http://www.ebi.ac.uk/pdbsum/3kwn PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kwn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kwn OCA], [http://pdbe.org/3kwn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kwn RCSB], [http://www.ebi.ac.uk/pdbsum/3kwn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kwn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kwn ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3kwn" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Cathepsin S]]
[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Bembenek, S D]]
[[Category: Bembenek, S D]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]

Revision as of 07:37, 5 August 2016

Cathepsin S in complex with Thioether Acetamide P3 inhibitor

3kwn, resolution 2.10Å

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