4hva

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==Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6==
==Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6==
<StructureSection load='4hva' size='340' side='right' caption='[[4hva]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
<StructureSection load='4hva' size='340' side='right' caption='[[4hva]], [[Resolution|resolution]] 2.07&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4hva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HVA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4hva]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HVA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HV:N-[(2R)-1-(3-CYANOPHENYL)-3-HYDROXYPROPAN-2-YL]-5-(3,4-DIMETHOXYPHENYL)FURAN-3-CARBOXAMIDE'>4HV</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4HV:N-[(2R)-1-(3-CYANOPHENYL)-3-HYDROXYPROPAN-2-YL]-5-(3,4-DIMETHOXYPHENYL)FURAN-3-CARBOXAMIDE'>4HV</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4H0:(3S)-3-AMINO-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC+ACID'>4H0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4H0:(3S)-3-AMINO-4-OXO-5-(2,3,5,6-TETRAFLUOROPHENOXY)PENTANOIC+ACID'>4H0</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CASP6, MCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Caspase-6 Caspase-6], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.59 3.4.22.59] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hva OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4hva RCSB], [http://www.ebi.ac.uk/pdbsum/4hva PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hva OCA], [http://pdbe.org/4hva PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hva RCSB], [http://www.ebi.ac.uk/pdbsum/4hva PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hva ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4hva" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Caspase-6]]
[[Category: Caspase-6]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Murray, J M]]
[[Category: Murray, J M]]
[[Category: Steffek, M]]
[[Category: Steffek, M]]

Revision as of 08:37, 5 August 2016

Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

4hva, resolution 2.07Å

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