4nr8
From Proteopedia
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==Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand== | ==Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand== | ||
<StructureSection load='4nr8' size='340' side='right' caption='[[4nr8]], [[Resolution|resolution]] 1.64Å' scene=''> | <StructureSection load='4nr8' size='340' side='right' caption='[[4nr8]], [[Resolution|resolution]] 1.64Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LL:5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE'>2LL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2LL:5-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-1-[2-(MORPHOLIN-4-YL)ETHYL]-2-(2-PHENYLETHYL)-1H-BENZIMIDAZOLE'>2LL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nr8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nr8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nr8 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nr8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nr8 OCA], [http://pdbe.org/4nr8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nr8 RCSB], [http://www.ebi.ac.uk/pdbsum/4nr8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nr8 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
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| + | ==See Also== | ||
| + | *[[Bromodomain-containing protein|Bromodomain-containing protein]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 08:41, 5 August 2016
Crystal structure of the first bromodomain of human BRD4 in complex with an isoxazolyl-benzimidazole ligand
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Categories: Human | Arrowsmith, C H | Bountra, C | Brennan, P | Delft, F Von | Edwards, A M | Fedorov, O | Felletar, I | Filippakopoulos, P | Hay, D | Knapp, S | Martin, S | Picaud, S | Structural genomic | Chemical tool | Sgc | Small molecule inhibitor | Transcription | Transcription-inhibitor complex
