4i1m

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[[Image:4i1m.png|left|200px]]
 
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{{STRUCTURE_4i1m| PDB=4i1m | SCENE= }}
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==Crystal structure of the Legionella pneumophila GAP domain of LepB==
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<StructureSection load='4i1m' size='340' side='right' caption='[[4i1m]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4i1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Legph Legph]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I1M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i1o|4i1o]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lepB, lpg2490 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=272624 LEGPH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i1m OCA], [http://pdbe.org/4i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i1m RCSB], [http://www.ebi.ac.uk/pdbsum/4i1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i1m ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Legionella pneumophila is an intracellularly surviving pathogen that releases about 270 different proteins into the host cell during infection. A set of secreted proteins takes control of the vesicular trafficking regulator Rab1. Legionella LepB inactivates Rab1 by acting as a GTPase-activating protein (GAP). We present the crystal structure of the Rab1b:LepB complex together with a thorough biochemical analysis and show that the GAP domain of LepB consists of an unusual fold. LepB acts by an atypical RabGAP mechanism that is reminiscent of classical GAPs and therefore sets the protein apart from mammalian TBC-like GAPs. Surprisingly, LepB can function as a GAP for Rab3, Rab8, Rab13 and Rab35, too, suggesting that it has a broader cellular role than previously thought.
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===Crystal structure of the Legionella pneumophila GAP domain of LepB===
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Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB.,Mihai Gazdag E, Streller A, Haneburger I, Hilbi H, Vetter IR, Goody RS, Itzen A EMBO Rep. 2013 Jan 4. doi: 10.1038/embor.2012.211. PMID:23288104<ref>PMID:23288104</ref>
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{{ABSTRACT_PUBMED_23288104}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 4i1m" style="background-color:#fffaf0;"></div>
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[[4i1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I1M OCA].
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== References ==
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[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
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<references/>
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[[Category: Gazdag, E M.]]
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__TOC__
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[[Category: Goody, R S.]]
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</StructureSection>
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[[Category: Itzen, A.]]
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[[Category: Legph]]
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[[Category: Streller, A.]]
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[[Category: Gazdag, E M]]
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[[Category: Vetter, I R.]]
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[[Category: Goody, R S]]
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[[Category: Itzen, A]]
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[[Category: Streller, A]]
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[[Category: Vetter, I R]]
[[Category: Gtp hydrolase]]
[[Category: Gtp hydrolase]]
[[Category: Gtpase-activating protein]]
[[Category: Gtpase-activating protein]]

Revision as of 09:00, 5 August 2016

Crystal structure of the Legionella pneumophila GAP domain of LepB

4i1m, resolution 2.80Å

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