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4jlt

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==Crystal structure of P450 2B4(H226Y) in complex with paroxetine==
==Crystal structure of P450 2B4(H226Y) in complex with paroxetine==
<StructureSection load='4jlt' size='340' side='right' caption='[[4jlt]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
<StructureSection load='4jlt' size='340' side='right' caption='[[4jlt]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4jlt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4jlt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JLT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JLT FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8PR:PAROXETINE'>8PR</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8PR:PAROXETINE'>8PR</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q6n|2q6n]], [[3kw4|3kw4]], [[2bdm|2bdm]], [[1suo|1suo]], [[3me6|3me6]], [[3mvr|3mvr]], [[3g5n|3g5n]], [[3r1a|3r1a]], [[3r1b|3r1b]], [[3g93|3g93]], [[1po5|1po5]], [[3uas|3uas]], [[4h1n|4h1n]], [[3tk3|3tk3]], [[3tmz|3tmz]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2q6n|2q6n]], [[3kw4|3kw4]], [[2bdm|2bdm]], [[1suo|1suo]], [[3me6|3me6]], [[3mvr|3mvr]], [[3g5n|3g5n]], [[3r1a|3r1a]], [[3r1b|3r1b]], [[3g93|3g93]], [[1po5|1po5]], [[3uas|3uas]], [[4h1n|4h1n]], [[3tk3|3tk3]], [[3tmz|3tmz]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2B4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 Oryctolagus cuniculus])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP2B4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9986 European rabbit])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jlt RCSB], [http://www.ebi.ac.uk/pdbsum/4jlt PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jlt OCA], [http://pdbe.org/4jlt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jlt RCSB], [http://www.ebi.ac.uk/pdbsum/4jlt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jlt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4jlt" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Oryctolagus cuniculus]]
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[[Category: European rabbit]]
[[Category: Unspecific monooxygenase]]
[[Category: Unspecific monooxygenase]]
[[Category: Halpert, J R]]
[[Category: Halpert, J R]]

Revision as of 09:49, 5 August 2016

Crystal structure of P450 2B4(H226Y) in complex with paroxetine

4jlt, resolution 2.14Å

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