3ziv
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_3ziv| PDB=3ziv | SCENE= }} | ||
| - | ===Crystal Structure of Ancestral Thioredoxin Relative to last Archaea- Eukaryotes Common Ancestor (AECA) from the Precambrian Period=== | ||
| - | {{ABSTRACT_PUBMED_23932589}} | ||
| - | == | + | ==Crystal Structure of Ancestral Thioredoxin Relative to last Archaea- Eukaryotes Common Ancestor (AECA) from the Precambrian Period== |
| - | [[3ziv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <StructureSection load='3ziv' size='340' side='right' caption='[[3ziv]], [[Resolution|resolution]] 2.65Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3ziv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZIV FirstGlance]. <br> | ||
| + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yj7|2yj7]], [[2yn1|2yn1]], [[2ynx|2ynx]], [[2yoi|2yoi]], [[2ypm|2ypm]], [[4ba7|4ba7]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ziv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ziv OCA], [http://pdbe.org/3ziv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ziv RCSB], [http://www.ebi.ac.uk/pdbsum/3ziv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ziv ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Little is known about the evolution of protein structures and the degree of protein structure conservation over planetary time scales. Here, we report the X-ray crystal structures of seven laboratory resurrections of Precambrian thioredoxins dating up to approximately four billion years ago. Despite considerable sequence differences compared with extant enzymes, the ancestral proteins display the canonical thioredoxin fold, whereas only small structural changes have occurred over four billion years. This remarkable degree of structure conservation since a time near the last common ancestor of life supports a punctuated-equilibrium model of structure evolution in which the generation of new folds occurs over comparatively short periods and is followed by long periods of structural stasis. | ||
| - | + | Conservation of Protein Structure over Four Billion Years.,Ingles-Prieto A, Ibarra-Molero B, Delgado-Delgado A, Perez-Jimenez R, Fernandez JM, Gaucher EA, Sanchez-Ruiz JM, Gavira JA Structure. 2013 Aug 6. pii: S0969-2126(13)00244-X. doi:, 10.1016/j.str.2013.06.020. PMID:23932589<ref>PMID:23932589</ref> | |
| - | <ref | + | |
| - | [[Category: Synthetic construct]] | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| + | </div> | ||
| + | <div class="pdbe-citations 3ziv" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Thioredoxin|Thioredoxin]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Synthetic construct sequences]] | ||
[[Category: Thioredoxin-disulfide reductase]] | [[Category: Thioredoxin-disulfide reductase]] | ||
| - | [[Category: Gavira, J A | + | [[Category: Gavira, J A]] |
| - | [[Category: Ibarra-Molero, B | + | [[Category: Ibarra-Molero, B]] |
| - | [[Category: Ingles-Prieto, A | + | [[Category: Ingles-Prieto, A]] |
| - | [[Category: Sanchez-Ruiz, J M | + | [[Category: Sanchez-Ruiz, J M]] |
[[Category: Ancestral reconstructed]] | [[Category: Ancestral reconstructed]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
Revision as of 09:51, 5 August 2016
Crystal Structure of Ancestral Thioredoxin Relative to last Archaea- Eukaryotes Common Ancestor (AECA) from the Precambrian Period
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