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3let
From Proteopedia
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==Crystal Structure of Fic domain containing AMPylator, VopS== | ==Crystal Structure of Fic domain containing AMPylator, VopS== | ||
<StructureSection load='3let' size='340' side='right' caption='[[3let]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='3let' size='340' side='right' caption='[[3let]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3let]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3let]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"oceanomonas_parahaemolytica"_(fujino_et_al._1951)_miyamoto_et_al._1961 "oceanomonas parahaemolytica" (fujino et al. 1951) miyamoto et al. 1961]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LET FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vopS, VP 1686, VP1686 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=670 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vopS, VP 1686, VP1686 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=670 "Oceanomonas parahaemolytica" (Fujino et al. 1951) Miyamoto et al. 1961])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide-nucleotide_adenylyltransferase Nicotinamide-nucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.1 2.7.7.1] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3let FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3let OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3let RCSB], [http://www.ebi.ac.uk/pdbsum/3let PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3let FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3let OCA], [http://pdbe.org/3let PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3let RCSB], [http://www.ebi.ac.uk/pdbsum/3let PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3let ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VOPS_VIBPA VOPS_VIBPA]] Adenylyltransferase involved in virulence by mediating the addition of adenosine 5'-monophosphate (AMP) to specific threonine residue of host Rho GTPases RhoA, Rac and Cdc42. The resulting AMPylation prevents the interaction of Rho GTPases with downstream effectors, thereby inhibiting actin assembly in infected cells.<ref>PMID:19039103</ref> <ref>PMID:20410310</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Nicotinamide-nucleotide adenylyltransferase]] | [[Category: Nicotinamide-nucleotide adenylyltransferase]] | ||
| - | [[Category: Vibrio parahaemolyticus]] | ||
[[Category: Brautigam, C A]] | [[Category: Brautigam, C A]] | ||
[[Category: Grishin, N V]] | [[Category: Grishin, N V]] | ||
Revision as of 10:08, 5 August 2016
Crystal Structure of Fic domain containing AMPylator, VopS
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