3pg4
From Proteopedia
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==The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)== | ==The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)== | ||
<StructureSection load='3pg4' size='340' side='right' caption='[[3pg4]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='3pg4' size='340' side='right' caption='[[3pg4]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3pg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3pg4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PG4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PG4 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla NDM-1, blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bla NDM-1, blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=573 "Bacillus pneumoniae" (Schroeter 1886) Flugge 1886])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg4 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pg4 OCA], [http://pdbe.org/3pg4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3pg4 RCSB], [http://www.ebi.ac.uk/pdbsum/3pg4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3pg4 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN]] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
==See Also== | ==See Also== | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Beta-lactamase]] | [[Category: Beta-lactamase]] | ||
| - | [[Category: Klebsiella pneumoniae]] | ||
[[Category: Chang,H J]] | [[Category: Chang,H J]] | ||
[[Category: Cho,Y S]] | [[Category: Cho,Y S]] | ||
[[Category: Kim,H T]] | [[Category: Kim,H T]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 10:16, 5 August 2016
The crystal structure of New Delhi Metallo-beta lactamase (NDM-1)
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Categories: Beta-lactamase | Chang,H J | Cho,Y S | Kim,H T | Hydrolase
