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3fof
From Proteopedia
(Difference between revisions)
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==Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases== | ==Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases== | ||
<StructureSection load='3fof' size='340' side='right' caption='[[3fof]], [[Resolution|resolution]] 4.00Å' scene=''> | <StructureSection load='3fof' size='340' side='right' caption='[[3fof]], [[Resolution|resolution]] 4.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3fof]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3fof]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3FOF FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MFX:1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-[(4AS,7AS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC+ACID'>MFX</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nov|2nov]], [[3foe|3foe]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nov|2nov]], [[3foe|3foe]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC, SP_0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC, SP_0855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886]), parE, SP_0852 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fof OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fof RCSB], [http://www.ebi.ac.uk/pdbsum/3fof PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fof OCA], [http://pdbe.org/3fof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fof RCSB], [http://www.ebi.ac.uk/pdbsum/3fof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fof ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fof ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3fof" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Streptococcus pneumoniae]] | ||
[[Category: Fisher, L M]] | [[Category: Fisher, L M]] | ||
[[Category: Laponogov, I]] | [[Category: Laponogov, I]] | ||
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[[Category: Protein-dna cleavage complex]] | [[Category: Protein-dna cleavage complex]] | ||
[[Category: Quinolone]] | [[Category: Quinolone]] | ||
| + | [[Category: Streptococcus pneumoniae]] | ||
[[Category: Topoisomerase]] | [[Category: Topoisomerase]] | ||
Revision as of 10:33, 5 August 2016
Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
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Categories: Fisher, L M | Laponogov, I | McAuley, K E | Pan, X S | Sanderson, M R | Sawhney, R | Sohi, M K | Thompson, A W | Veselkov, D A | Atp-binding | Cell membrane | Dna | Dna-binding | Isomerase | Isomerase-dna complex | Membrane | Moxifloxacin | Nucleotide-binding | Protein-dna cleavage complex | Quinolone | Streptococcus pneumoniae | Topoisomerase
