1mdg

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|PDB= 1mdg |SIZE=350|CAPTION= <scene name='initialview01'>1mdg</scene>, resolution 1.50&Aring;
|PDB= 1mdg |SIZE=350|CAPTION= <scene name='initialview01'>1mdg</scene>, resolution 1.50&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> and <scene name='pdbligand=NCO:COBALT HEXAMMINE ION'>NCO</scene>
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BGM:8-BROMO-2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>BGM</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE+ION'>NCO</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
|ACTIVITY=
|ACTIVITY=
|GENE=
|GENE=
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|DOMAIN=
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mdg OCA], [http://www.ebi.ac.uk/pdbsum/1mdg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mdg RCSB]</span>
}}
}}
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[[Category: Sundaralingam, M.]]
[[Category: Sundaralingam, M.]]
[[Category: Xiong, Y.]]
[[Category: Xiong, Y.]]
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[[Category: NA]]
 
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[[Category: NCO]]
 
[[Category: base octad]]
[[Category: base octad]]
[[Category: base tetrad]]
[[Category: base tetrad]]
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[[Category: tetraplex]]
[[Category: tetraplex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:42:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:14:41 2008''

Revision as of 19:14, 30 March 2008

Image:1mdg.gif


PDB ID 1mdg

Drag the structure with the mouse to rotate
, resolution 1.50Å
Ligands: , , , , ,
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



An Alternating Antiparallel Octaplex in an RNA Crystal Structure


Overview

Multistranded helical structures in nucleic acids play various functions in biological processes. Here we report the crystal structure of a hexamer, rU(BrdG)r(AGGU),at 1.5 A resolution containing a structural complex of an alternating antiparallel eight-stranded helical fragment that is sandwiched in two tetraplexes. The octaplex is formed by groove binding interaction and base tetrad intercalation between two tetraplexes. Two different forms of octaplexes have been proposed, which display different properties in interaction with proteins and nucleic acids. Adenines form a base tetrad in the novel N6-H em leader N3 conformation and further interact with uridines to form an adenine-uridine octad in the reverse Hoogsteen pairing scheme. The conformational flexibility of adenine tetrad indicates that it can optimize its conformation in different interactions.

About this Structure

1MDG is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

An eight-stranded helical fragment in RNA crystal structure: implications for tetraplex interaction., Pan B, Xiong Y, Shi K, Sundaralingam M, Structure. 2003 Jul;11(7):825-31. PMID:12842045

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