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3vha

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==Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor==
==Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor==
<StructureSection load='3vha' size='340' side='right' caption='[[3vha]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
<StructureSection load='3vha' size='340' side='right' caption='[[3vha]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3vha]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VHA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3vha]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VHA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VHA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=VHA:22-METHYL-13,18-DIOXA-7-THIA-3,5-DIAZATETRACYCLO[17.3.1.1~2,6~.1~8,12~]PENTACOSA-1(23),2(25),3,5,8(24),9,11,19,21-NONAEN-4-AMINE'>VHA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=VHA:22-METHYL-13,18-DIOXA-7-THIA-3,5-DIAZATETRACYCLO[17.3.1.1~2,6~.1~8,12~]PENTACOSA-1(23),2(25),3,5,8(24),9,11,19,21-NONAEN-4-AMINE'>VHA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b24|3b24]], [[3b25|3b25]], [[3b26|3b26]], [[3b27|3b27]], [[3b28|3b28]], [[3vhc|3vhc]], [[3vhd|3vhd]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3b24|3b24]], [[3b25|3b25]], [[3b26|3b26]], [[3b27|3b27]], [[3b28|3b28]], [[3vhc|3vhc]], [[3vhd|3vhd]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP90AA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vha OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vha RCSB], [http://www.ebi.ac.uk/pdbsum/3vha PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vha OCA], [http://pdbe.org/3vha PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3vha RCSB], [http://www.ebi.ac.uk/pdbsum/3vha PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3vha ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3vha" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Fukami, T A]]
[[Category: Fukami, T A]]
[[Category: Ono, N]]
[[Category: Ono, N]]
[[Category: Chaperone-chaperone inhibitor complex]]
[[Category: Chaperone-chaperone inhibitor complex]]

Revision as of 11:19, 5 August 2016

Hsp90 alpha N-terminal domain in complex with a macrocyclic inhibitor

3vha, resolution 1.39Å

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