1me4
From Proteopedia
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|PDB= 1me4 |SIZE=350|CAPTION= <scene name='initialview01'>1me4</scene>, resolution 1.2Å | |PDB= 1me4 |SIZE=350|CAPTION= <scene name='initialview01'>1me4</scene>, resolution 1.2Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=T10:[1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER'>T10</scene> | + | |LIGAND= <scene name='pdbligand=T10:[1-(1-BENZYL-3-HYDROXY-2-OXO-PROPYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC+ACID+BENZYL+ESTER'>T10</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1f29|1f29]], [[1f2a|1f2a]], [[1f2c|1f2c]], [[1f2b|1f2b]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1me4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1me4 OCA], [http://www.ebi.ac.uk/pdbsum/1me4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1me4 RCSB]</span> | ||
}} | }} | ||
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[[Category: Ellman, J A.]] | [[Category: Ellman, J A.]] | ||
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
| - | [[Category: T10]] | ||
[[Category: cysteine protease]] | [[Category: cysteine protease]] | ||
[[Category: non-covalent inhibitor]] | [[Category: non-covalent inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:15:01 2008'' |
Revision as of 19:15, 30 March 2008
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| , resolution 1.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Related: | 1f29, 1f2a, 1f2c, 1f2b
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (I)
Overview
The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
About this Structure
1ME4 is a Single protein structure of sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
Reference
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
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