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4kpf
From Proteopedia
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==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate== | ==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate== | ||
<StructureSection load='4kpf' size='340' side='right' caption='[[4kpf]], [[Resolution|resolution]] 3.24Å' scene=''> | <StructureSection load='4kpf' size='340' side='right' caption='[[4kpf]], [[Resolution|resolution]] 3.24Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1UV:(3AS,4R)-4-AMINO-13-CYCLOPROPYL-8-FLUORO-10-OXO-3A,4,5,6,10,13-HEXAHYDRO-1H,3H-PYRROLO[2,1 3,4][1,4]OXAZEPINO[5,6-H]QUINOLINE-11-CARBOXYLIC+ACID'>1UV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1UV:(3AS,4R)-4-AMINO-13-CYCLOPROPYL-8-FLUORO-10-OXO-3A,4,5,6,10,13-HEXAHYDRO-1H,3H-PYRROLO[2,1 3,4][1,4]OXAZEPINO[5,6-H]QUINOLINE-11-CARBOXYLIC+ACID'>1UV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpe|4kpe]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpe|4kpe]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpf RCSB], [http://www.ebi.ac.uk/pdbsum/4kpf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpf OCA], [http://pdbe.org/4kpf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kpf RCSB], [http://www.ebi.ac.uk/pdbsum/4kpf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpf ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | [[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | ||
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| - | ==See Also== | ||
| - | *[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 11:31, 5 August 2016
Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate
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