4n9u
From Proteopedia
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==The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ==The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates== | ||
<StructureSection load='4n9u' size='340' side='right' caption='[[4n9u]], [[Resolution|resolution]] 2.11Å' scene=''> | <StructureSection load='4n9u' size='340' side='right' caption='[[4n9u]], [[Resolution|resolution]] 2.11Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RIS:1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE+BIS-PHOSPHONIC+ACID'>RIS</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kq5|4kq5]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[1yq7|1yq7]], [[4nua|4nua]], [[4ng6|4ng6]], [[4nke|4nke]], [[4nkf|4nkf]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kfa|4kfa]], [[4kpd|4kpd]], [[4kpj|4kpj]], [[4kq5|4kq5]], [[4kqs|4kqs]], [[4kqu|4kqu]], [[1yq7|1yq7]], [[4nua|4nua]], [[4ng6|4ng6]], [[4nke|4nke]], [[4nkf|4nkf]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://pdbe.org/4n9u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4n9u ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
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| + | ==See Also== | ||
| + | *[[Farnesyl diphosphate synthase|Farnesyl diphosphate synthase]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:37, 5 August 2016
The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
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Categories: Barnett, B L | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha-helical prenyltransferase fold | Dimethylallyl pyrophosphate | Isopentenyl pyrophosphate | Isoprene biosynthesis | Lipid synthesis | Steroid biosynthesis | Transferase
