2xus
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION== | ==CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION== | ||
<StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution|resolution]] 1.91Å' scene=''> | <StructureSection load='2xus' size='340' side='right' caption='[[2xus]], [[Resolution|resolution]] 1.91Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2xus]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XUS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XUS FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xus OCA], [http://pdbe.org/2xus PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xus RCSB], [http://www.ebi.ac.uk/pdbsum/2xus PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xus ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRMS1_HUMAN BRMS1_HUMAN]] Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.<ref>PMID:14581478</ref> <ref>PMID:17000776</ref> <ref>PMID:20830743</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2xus" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Bravo, J]] | [[Category: Bravo, J]] | ||
[[Category: Neira, J L]] | [[Category: Neira, J L]] | ||
Revision as of 12:26, 5 August 2016
CRYSTAL STRUCTURE OF THE BRMS1 N-TERMINAL REGION
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