3uqu
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of BACE1 with its inhibitor== | ==Crystal structure of BACE1 with its inhibitor== | ||
<StructureSection load='3uqu' size='340' side='right' caption='[[3uqu]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='3uqu' size='340' side='right' caption='[[3uqu]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3uqu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3uqu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UQU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UQU FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene>, <scene name='pdbligand=ZPX:N-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-N-[(2S,3S)-3-HYDROXY-1-PHENYL-4-(1H-PYRAZOL-1-YL)BUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZENE-1,3-DICARBOXAMIDE'>ZPX</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene>, <scene name='pdbligand=ZPX:N-[(1R)-1-(4-FLUOROPHENYL)ETHYL]-N-[(2S,3S)-3-HYDROXY-1-PHENYL-4-(1H-PYRAZOL-1-YL)BUTAN-2-YL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZENE-1,3-DICARBOXAMIDE'>ZPX</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uqp|3uqp]], [[4dv9|4dv9]], [[3uqr|3uqr]], [[4dvf|4dvf]], [[3uqw|3uqw]], [[3uqx|3uqx]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uqp|3uqp]], [[4dv9|4dv9]], [[3uqr|3uqr]], [[4dvf|4dvf]], [[3uqw|3uqw]], [[3uqx|3uqx]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uqu RCSB], [http://www.ebi.ac.uk/pdbsum/3uqu PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uqu OCA], [http://pdbe.org/3uqu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3uqu RCSB], [http://www.ebi.ac.uk/pdbsum/3uqu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3uqu ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| Line 18: | Line 19: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Chen, T T]] | [[Category: Chen, T T]] | ||
Revision as of 12:27, 5 August 2016
Crystal structure of BACE1 with its inhibitor
| |||||||||||
