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3i59
From Proteopedia
(Difference between revisions)
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==Crystal structure of MtbCRP in complex with N6-cAMP== | ==Crystal structure of MtbCRP in complex with N6-cAMP== | ||
<StructureSection load='3i59' size='340' side='right' caption='[[3i59]], [[Resolution|resolution]] 2.29Å' scene=''> | <StructureSection load='3i59' size='340' side='right' caption='[[3i59]], [[Resolution|resolution]] 2.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3i59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3i59]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3I59 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6R:(2R)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6R</scene>, <scene name='pdbligand=N6S:(2S)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6S</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=N6R:(2R)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6R</scene>, <scene name='pdbligand=N6S:(2S)-N6-(1-METHYL-2-PHENYLETHYL)ADENOSINE-3,5-CYCLIC+MONOPHOSPHATE'>N6S</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i54|3i54]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3i54|3i54]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3777, Rv3676 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT3777, Rv3676 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i59 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3i59 RCSB], [http://www.ebi.ac.uk/pdbsum/3i59 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i59 OCA], [http://pdbe.org/3i59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3i59 RCSB], [http://www.ebi.ac.uk/pdbsum/3i59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3i59 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/CRP_MYCTO CRP_MYCTO]] Global transcriptional regulator that complexes with cAMP and binds to specific DNA promoter sites, causing DNA-bending, to regulate transcription. cAMP improves binding to specific DNA sequences, probably by altering protein conformation. Activates expression of whiB1.<ref>PMID:16946269</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i59 ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3i59" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Bruning, J B]] | [[Category: Bruning, J B]] | ||
[[Category: Palaninathan, S K]] | [[Category: Palaninathan, S K]] | ||
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[[Category: Dna-binding]] | [[Category: Dna-binding]] | ||
[[Category: Inhibition]] | [[Category: Inhibition]] | ||
| + | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: N6-camp]] | [[Category: N6-camp]] | ||
[[Category: Tbsgc]] | [[Category: Tbsgc]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
[[Category: Transcription regulation]] | [[Category: Transcription regulation]] | ||
Revision as of 12:30, 5 August 2016
Crystal structure of MtbCRP in complex with N6-cAMP
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Categories: Bruning, J B | Palaninathan, S K | Reddy, M C | Sacchettini, J C | Smith, D | Structural genomic | Thurman, C | Allosteric mechanism | Camp receptor protein | Crp | Dna binding | Dna binding protein | Dna-binding | Inhibition | Mycobacterium tuberculosis | N6-camp | Tbsgc | Transcription | Transcription regulation
