4g2b

From Proteopedia

(Difference between revisions)

Revision as of 12:31, 5 August 2016

Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

Structural highlights

4g2b is a 2 chain structure with sequence from Salty. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	4g29
Gene:	sseI, srfH, STM1051 (SALTY)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SSEI_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is required to maintain a long-term chronic systemic infection in mice. It inhibits normal cell migration of primary macrophages and dendritic cells, by a mechanism that involves interaction with the host factor IQGAP1, an important regulator of the cytoskeleton and cell migration. Also accelerates the systemic spread of infection from the gastrointestinal tract to the bloodstream, probably by interacting with host TRIP6.^[1] ^[2]

Publication Abstract from PubMed

SseI is secreted into host cells by Salmonella and contributes to the establishment of systemic infections. The crystal structure of the C-terminal domain of SseI has been solved to 1.70 A resolution, revealing it to be a member of the cysteine protease superfamily with a catalytic triad consisting of Cys178, His216 and Asp231 that is critical to its virulence activities. Structure-based analysis revealed that SseI is likely to possess either acyl hydrolase or acyltransferase activity, placing this virulence factor in the rapidly growing class of enzymes of this family utilized by bacterial pathogens inside eukaryotic cells.

Structure of the catalytic domain of the Salmonella virulence factor SseI.,Bhaskaran SS, Stebbins CE Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1613-21. doi:, 10.1107/S0907444912039042. Epub 2012 Nov 9. PMID:23151626^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Worley MJ, Nieman GS, Geddes K, Heffron F. Salmonella typhimurium disseminates within its host by manipulating the motility of infected cells. Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17915-20. Epub 2006 Nov 9. PMID:17095609 doi:http://dx.doi.org/10.1073/pnas.0604054103
↑ McLaughlin LM, Govoni GR, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien YH, Jeong HW, Li Z, Brown MD, Sacks DB, Monack D. The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration. PLoS Pathog. 2009 Nov;5(11):e1000671. doi: 10.1371/journal.ppat.1000671. Epub, 2009 Nov 26. PMID:19956712 doi:http://dx.doi.org/10.1371/journal.ppat.1000671
↑ Bhaskaran SS, Stebbins CE. Structure of the catalytic domain of the Salmonella virulence factor SseI. Acta Crystallogr D Biol Crystallogr. 2012 Dec;68(Pt 12):1613-21. doi:, 10.1107/S0907444912039042. Epub 2012 Nov 9. PMID:23151626 doi:http://dx.doi.org/10.1107/S0907444912039042

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4g2b"

Categories: Salty | Bhaskaran, S S | Stebbins, C E | Cysteine protease superfamily | Protein binding

@@ Line 1: / Line 1: @@
 ==Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI==
 <StructureSection load='4g2b' size='340' side='right' caption='[[4g2b]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium_str._lt2 Salmonella enterica subsp. enterica serovar typhimurium str. lt2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4g2b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4G2B FirstGlance]. <br>
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4g29|4g29]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sseI, srfH, STM1051 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4g2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g2b OCA], [http://pdbe.org/4g2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4g2b RCSB], [http://www.ebi.ac.uk/pdbsum/4g2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4g2b ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 17: / Line 18: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4g2b" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Salmonella enterica subsp. enterica serovar typhimurium str. lt2]]
+[[Category: Salty]]
 [[Category: Bhaskaran, S S]]
 [[Category: Stebbins, C E]]
 [[Category: Cysteine protease superfamily]]
 [[Category: Protein binding]]

4g2b

From Proteopedia

Revision as of 12:31, 5 August 2016

Structure of the Catalytic Domain of the Salmonella Virulence Factor SseI

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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