1mix
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1miz|1MIZ]], [[1mk7|1MK7]], [[1mk9|1MK9]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mix OCA], [http://www.ebi.ac.uk/pdbsum/1mix PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mix RCSB]</span> | ||
}} | }} | ||
| Line 35: | Line 38: | ||
[[Category: integrin binding]] | [[Category: integrin binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:16:38 2008'' |
Revision as of 19:16, 30 March 2008
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| , resolution 1.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Related: | 1MIZ, 1MK7, 1MK9
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a FERM domain of Talin
Overview
The binding of cytoplasmic proteins, such as talin, to the cytoplasmic domains of integrin adhesion receptors mediates bidirectional signal transduction. Here we report the crystal structure of the principal integrin binding and activating fragment of talin, alone and in complex with fragments of the beta 3 integrin tail. The FERM (four point one, ezrin, radixin, and moesin) domain of talin engages integrins via a novel variant of the canonical phosphotyrosine binding (PTB) domain-NPxY ligand interaction that may be a prototype for FERM domain recognition of transmembrane receptors. In combination with NMR and mutational analysis, our studies reveal the critical interacting elements of both talin and the integrin beta 3 tail, providing structural paradigms for integrin linkage to the cell interior.
About this Structure
1MIX is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
Structural determinants of integrin recognition by talin., Garcia-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC, Mol Cell. 2003 Jan;11(1):49-58. PMID:12535520
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