2xrc
From Proteopedia
(Difference between revisions)
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==HUMAN COMPLEMENT FACTOR I== | ==HUMAN COMPLEMENT FACTOR I== | ||
<StructureSection load='2xrc' size='340' side='right' caption='[[2xrc]], [[Resolution|resolution]] 2.69Å' scene=''> | <StructureSection load='2xrc' size='340' side='right' caption='[[2xrc]], [[Resolution|resolution]] 2.69Å' scene=''> | ||
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_factor_I Complement factor I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.45 3.4.21.45] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Complement_factor_I Complement factor I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.45 3.4.21.45] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xrc RCSB], [http://www.ebi.ac.uk/pdbsum/2xrc PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xrc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xrc OCA], [http://pdbe.org/2xrc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xrc RCSB], [http://www.ebi.ac.uk/pdbsum/2xrc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xrc ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN]] HELLP syndrome;Immunodeficiency with factor I anomaly;De novo thrombotic microangiopathy after kidney transplantation;Atypical hemolytic-uremic syndrome with I factor anomaly;Age-related macular degeneration. Disease susceptibility is associated with variations affecting the gene represented in this entry. Other genes may play a role in modifying the phenotype. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CFAI_HUMAN CFAI_HUMAN]] Responsible for cleaving the alpha-chains of C4b and C3b in the presence of the cofactors C4-binding protein and factor H respectively. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2xrc" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:06, 5 August 2016
HUMAN COMPLEMENT FACTOR I
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