3ovz

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==Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead==
==Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead==
<StructureSection load='3ovz' size='340' side='right' caption='[[3ovz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='3ovz' size='340' side='right' caption='[[3ovz]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ovz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OVZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ovz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OVZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O96:N-[(1S)-3-AMINO-1-ETHYL-2,3-DIOXOPROPYL]-2-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-3-(TRIFLUOROMETHYL)BENZAMIDE'>O96</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=O96:N-[(1S)-3-AMINO-1-ETHYL-2,3-DIOXOPROPYL]-2-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-3-(TRIFLUOROMETHYL)BENZAMIDE'>O96</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ovx|3ovx]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ovx|3ovx]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CTSK, CTSO, CTSO2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ovz RCSB], [http://www.ebi.ac.uk/pdbsum/3ovz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ovz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovz OCA], [http://pdbe.org/3ovz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ovz RCSB], [http://www.ebi.ac.uk/pdbsum/3ovz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovz ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3ovz" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Cathepsin K]]
[[Category: Cathepsin K]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Fradera, X]]
[[Category: Fradera, X]]
[[Category: Uitdehaag, J C.M]]
[[Category: Uitdehaag, J C.M]]

Revision as of 14:18, 5 August 2016

Cathepsin K in complex with a covalent inhibitor with a ketoamide warhead

3ovz, resolution 2.02Å

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