4h43
From Proteopedia
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==Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.== | ==Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.== | ||
<StructureSection load='4h43' size='340' side='right' caption='[[4h43]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='4h43' size='340' side='right' caption='[[4h43]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4h43]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4h43]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Salty Salty]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H43 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mkaD, PSLT038, salmonella plasmid virulence (spv), spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mkaD, PSLT038, salmonella plasmid virulence (spv), spvC, vsdD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=99287 SALTY])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h43 RCSB], [http://www.ebi.ac.uk/pdbsum/4h43 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h43 OCA], [http://pdbe.org/4h43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h43 RCSB], [http://www.ebi.ac.uk/pdbsum/4h43 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h43 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY]] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Salty]] |
[[Category: Hengge, A C]] | [[Category: Hengge, A C]] | ||
[[Category: Johnson, S J]] | [[Category: Johnson, S J]] | ||
Revision as of 15:35, 5 August 2016
Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.
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