4jkr
From Proteopedia
(Difference between revisions)
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| + | {{Large structure}} | ||
==Crystal Structure of E. coli RNA Polymerase in complex with ppGpp== | ==Crystal Structure of E. coli RNA Polymerase in complex with ppGpp== | ||
<StructureSection load='4jkr' size='340' side='right' caption='[[4jkr]], [[Resolution|resolution]] 4.20Å' scene=''> | <StructureSection load='4jkr' size='340' side='right' caption='[[4jkr]], [[Resolution|resolution]] 4.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4jkr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4jkr]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Eco1e Eco1e], [http://en.wikipedia.org/wiki/Ecobw Ecobw], [http://en.wikipedia.org/wiki/Ecod1 Ecod1] and [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JKR FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECDH10B_3470, O3O_23125, rpoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1133853 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECDH10B_3470, O3O_23125, rpoA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1133853 ECO1E]), ECDH1ME8569_3846, EcDH1_4008, O3K_23925, rpoB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=536056 ECOD1]), BWG_3647, O3O_01425, rpoC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=595496 ECOBW]), ECDH1ME8569_3534, EcDH1_0056, O3O_25075, rpoZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=536056 ECOD1]), alt, b3067, JW3039, rpoD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jkr RCSB], [http://www.ebi.ac.uk/pdbsum/4jkr PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jkr OCA], [http://pdbe.org/4jkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jkr RCSB], [http://www.ebi.ac.uk/pdbsum/4jkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jkr ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/C9QUL2_ECOD1 C9QUL2_ECOD1]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).[HAMAP-Rule:MF_00366][SAAS:SAAS012293_004_017283] [[http://www.uniprot.org/uniprot/K0BPQ3_ECO1E K0BPQ3_ECO1E]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/C5A0S8_ECOBW C5A0S8_ECOBW]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[SAAS:SAAS012754_004_011999] [[http://www.uniprot.org/uniprot/C9QV90_ECOD1 C9QV90_ECOD1]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[HAMAP-Rule:MF_01321][RuleBase:RU000432] [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium. | [[http://www.uniprot.org/uniprot/C9QUL2_ECOD1 C9QUL2_ECOD1]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).[HAMAP-Rule:MF_00366][SAAS:SAAS012293_004_017283] [[http://www.uniprot.org/uniprot/K0BPQ3_ECO1E K0BPQ3_ECO1E]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[HAMAP-Rule:MF_00059] [[http://www.uniprot.org/uniprot/C5A0S8_ECOBW C5A0S8_ECOBW]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[SAAS:SAAS012754_004_011999] [[http://www.uniprot.org/uniprot/C9QV90_ECOD1 C9QV90_ECOD1]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity).[HAMAP-Rule:MF_01321][RuleBase:RU000432] [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium. | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4jkr" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[RNA polymerase|RNA polymerase]] | *[[RNA polymerase|RNA polymerase]] | ||
| + | *[[Sigma factor|Sigma factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: DNA-directed RNA polymerase]] | [[Category: DNA-directed RNA polymerase]] | ||
| - | [[Category: | + | [[Category: Eco1e]] |
| - | [[Category: | + | [[Category: Ecobw]] |
| - | [[Category: | + | [[Category: Ecod1]] |
| - | [[Category: | + | [[Category: Ecoli]] |
[[Category: Steitz, T A]] | [[Category: Steitz, T A]] | ||
[[Category: Wang, Y]] | [[Category: Wang, Y]] | ||
Revision as of 16:07, 5 August 2016
Warning: this is a large structure, and loading might take a long time or not happen at all.
Crystal Structure of E. coli RNA Polymerase in complex with ppGpp
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