4bbx

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==Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia==
==Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia==
<StructureSection load='4bbx' size='340' side='right' caption='[[4bbx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4bbx' size='340' side='right' caption='[[4bbx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LKF:4-[3-[1-[(2S)-2-METHOXYPROPYL]PYRAZOL-4-YL]-2-METHYL-IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>LKF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LKF:4-[3-[1-[(2S)-2-METHOXYPROPYL]PYRAZOL-4-YL]-2-METHYL-IMIDAZO[1,2-A]PYRAZIN-8-YL]MORPHOLINE'>LKF</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajf|4ajf]], [[4ajg|4ajg]], [[4ajm|4ajm]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lrb|1lrb]], [[2wey|2wey]], [[2y0j|2y0j]], [[4ael|4ael]], [[4ajd|4ajd]], [[4ajf|4ajf]], [[4ajg|4ajg]], [[4ajm|4ajm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4bbx RCSB], [http://www.ebi.ac.uk/pdbsum/4bbx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4bbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4bbx OCA], [http://pdbe.org/4bbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4bbx RCSB], [http://www.ebi.ac.uk/pdbsum/4bbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4bbx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4bbx" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==

Revision as of 16:50, 5 August 2016

Discovery of a potent, selective and orally active PDE10A inhibitor for the treatment of schizophrenia

4bbx, resolution 2.50Å

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