2xq9

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==PENTAMERIC LIGAND GATED ION CHANNEL GLIC MUTANT E221A IN COMPLEX WITH TETRAETHYLARSONIUM (TEAS)==
==PENTAMERIC LIGAND GATED ION CHANNEL GLIC MUTANT E221A IN COMPLEX WITH TETRAETHYLARSONIUM (TEAS)==
<StructureSection load='2xq9' size='340' side='right' caption='[[2xq9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='2xq9' size='340' side='right' caption='[[2xq9]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xq9]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xq9]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Glovi Glovi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XQ9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XQ9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ARS:ARSENIC'>ARS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xqa|2xqa]], [[2xq7|2xq7]], [[2xq5|2xq5]], [[2xq3|2xq3]], [[2xq8|2xq8]], [[2xq4|2xq4]], [[2xq6|2xq6]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xqa|2xqa]], [[2xq7|2xq7]], [[2xq5|2xq5]], [[2xq3|2xq3]], [[2xq8|2xq8]], [[2xq4|2xq4]], [[2xq6|2xq6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xq9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xq9 OCA], [http://pdbe.org/2xq9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xq9 RCSB], [http://www.ebi.ac.uk/pdbsum/2xq9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xq9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q7NDN8_GLOVI Q7NDN8_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xq9" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Gloeobacter violaceus pcc 7421]]
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[[Category: Glovi]]
[[Category: Bertozzi, C]]
[[Category: Bertozzi, C]]
[[Category: Dutzler, R]]
[[Category: Dutzler, R]]

Revision as of 17:11, 5 August 2016

PENTAMERIC LIGAND GATED ION CHANNEL GLIC MUTANT E221A IN COMPLEX WITH TETRAETHYLARSONIUM (TEAS)

2xq9, resolution 3.20Å

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