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4acq
From Proteopedia
(Difference between revisions)
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| + | {{Large structure}} | ||
==Alpha-2 Macroglobulin== | ==Alpha-2 Macroglobulin== | ||
<StructureSection load='4acq' size='340' side='right' caption='[[4acq]], [[Resolution|resolution]] 4.30Å' scene=''> | <StructureSection load='4acq' size='340' side='right' caption='[[4acq]], [[Resolution|resolution]] 4.30Å' scene=''> | ||
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MEQ:N5-METHYLGLUTAMINE'>MEQ</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bv8|1bv8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1bv8|1bv8]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4acq RCSB], [http://www.ebi.ac.uk/pdbsum/4acq PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4acq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4acq OCA], [http://pdbe.org/4acq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4acq RCSB], [http://www.ebi.ac.uk/pdbsum/4acq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4acq ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | {{Large structure}} | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN]] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. | [[http://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN]] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4acq" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 17:42, 5 August 2016
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Alpha-2 Macroglobulin
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