1mu4
From Proteopedia
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|PDB= 1mu4 |SIZE=350|CAPTION= <scene name='initialview01'>1mu4</scene>, resolution 1.80Å | |PDB= 1mu4 |SIZE=350|CAPTION= <scene name='initialview01'>1mu4</scene>, resolution 1.80Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1mo1|1MO1]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mu4 OCA], [http://www.ebi.ac.uk/pdbsum/1mu4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mu4 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Haser, R.]] | [[Category: Haser, R.]] | ||
[[Category: Juy, M R.]] | [[Category: Juy, M R.]] | ||
| - | [[Category: SO4]] | ||
[[Category: open-faced b-sandwich]] | [[Category: open-faced b-sandwich]] | ||
[[Category: phosphotransferase system]] | [[Category: phosphotransferase system]] | ||
[[Category: swapping domain]] | [[Category: swapping domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:07 2008'' |
Revision as of 19:21, 30 March 2008
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| , resolution 1.80Å | |||||||
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| Ligands: | |||||||
| Related: | 1MO1
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE AT 1.8 ANGSTROMS OF THE BACILLUS SUBTILIS CATABOLITE REPRESSION HISTIDINE CONTAINING PROTEIN (CRH)
Overview
The crystal structure of the regulatory protein Crh from Bacillus subtilis was solved at 1.8A resolution and showed an intertwined dimer formed by N-terminal beta1-strand swapping of two monomers. Comparison with the monomeric NMR structure of Crh revealed a domain swap induced conformational rearrangement of the putative interaction site with the repressor CcpA. The resulting conformation closely resembles that observed for the monomeric Crh homologue HPr, indicating that the Crh dimer is the active form binding to CcpA. An analogous dimer of HPr can be constructed without domain swapping, suggesting that HPr may dimerize upon binding to CcpA. Our data suggest that reversible 3D domain swapping of Crh might be an efficient regulatory mechanism to modulate its activity.
About this Structure
1MU4 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.
Reference
Dimerization of Crh by reversible 3D domain swapping induces structural adjustments to its monomeric homologue Hpr., Juy M, Penin F, Favier A, Galinier A, Montserret R, Haser R, Deutscher J, Bockmann A, J Mol Biol. 2003 Sep 26;332(4):767-76. PMID:12972249
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