1muf
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1muf |SIZE=350|CAPTION= <scene name='initialview01'>1muf</scene>, resolution 2.26Å | |PDB= 1muf |SIZE=350|CAPTION= <scene name='initialview01'>1muf</scene>, resolution 2.26Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone-lysine_N-methyltransferase Histone-lysine N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.43 2.1.1.43] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1mt6|1MT6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1muf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1muf OCA], [http://www.ebi.ac.uk/pdbsum/1muf PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1muf RCSB]</span> | ||
}} | }} | ||
| Line 33: | Line 36: | ||
[[Category: set domain]] | [[Category: set domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:21:14 2008'' |
Revision as of 19:21, 30 March 2008
| |||||||
| , resolution 2.26Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Activity: | Histone-lysine N-methyltransferase, with EC number 2.1.1.43 | ||||||
| Related: | 1MT6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of histone H3 K4-specific methyltransferase SET7/9
Overview
The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
About this Structure
1MUF is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The active site of the SET domain is constructed on a knot., Jacobs SA, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khorasanizadeh S, Nat Struct Biol. 2002 Nov;9(11):833-8. PMID:12389038
Page seeded by OCA on Sun Mar 30 22:21:14 2008
