4d9s

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[[Image:4d9s.jpg|left|200px]]
 
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==Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)==
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The line below this paragraph, containing "STRUCTURE_4d9s", creates the "Structure Box" on the page.
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<StructureSection load='4d9s' size='340' side='right' caption='[[4d9s]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4d9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D9S FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UVR8, At5g63860, AT5G63860 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d9s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9s OCA], [http://pdbe.org/4d9s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4d9s RCSB], [http://www.ebi.ac.uk/pdbsum/4d9s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9s ProSAT]</span></td></tr>
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{{STRUCTURE_4d9s| PDB=4d9s | SCENE= }}
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/UVR8_ARATH UVR8_ARATH]] UV-B specific signaling component that acts as UV-B photoreceptor and plays a key role in establishing UV-protective responses in plants. Upon UV-B irradiation, UVR8 undergoes an immediate switch from homodimer to monomer, accumulates in the nucleus, interacts with the photomorphogenic repressor COP1 and regulates the expression of the transcription factor HY5 by associating with chromatin (through histone H2B binding) in the HY5 promoter region. UVR8 is involved in controlling aspects of leaf growth and morphogenesis in response to UV-B, is required for normal progression of endocycle and has a regulatory role in stomatal differentiation. Is required for plant circadian clock response to photomorphogenic UV-B light, partly through the transcriptional activation of responsive clock genes. Promotes photosynthetic efficiency at elevated levels of UV-B. Plays a role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway. The two tryptophans, Trp-285 and Trp-233, serve collectively as the UV-B chromophore.<ref>PMID:16330762</ref> <ref>PMID:17720867</ref> <ref>PMID:18055587</ref> <ref>PMID:19165148</ref> <ref>PMID:19402876</ref> <ref>PMID:21041653</ref> <ref>PMID:21395889</ref> <ref>PMID:21454788</ref> <ref>PMID:22447155</ref> <ref>PMID:23161229</ref> <ref>PMID:23012433</ref> <ref>PMID:22988111</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The recently identified plant photoreceptor UVR8 (UV RESISTANCE LOCUS 8) triggers regulatory changes in gene expression in response to ultraviolet-B (UV-B) light through an unknown mechanism. Here, crystallographic and solution structures of the UVR8 homodimer, together with mutagenesis and far-UV circular dichroism spectroscopy, reveal its mechanisms for UV-B perception and signal transduction. beta-propeller subunits form a remarkable, tryptophan-dominated, dimer interface stitched together by a complex salt-bridge network. Salt-bridging arginines flank the excitonically coupled cross-dimer tryptophan "pyramid" responsible for UV-B sensing. Photoreception reversibly disrupts salt bridges, triggering dimer dissociation and signal initiation. Mutation of a single tryptophan to phenylalanine retunes the photoreceptor to detect UV-C wavelengths. Our analyses establish how UVR8 functions as a photoreceptor without a prosthetic chromophore to promote plant development and survival in sunlight.
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===Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)===
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Plant UVR8 photoreceptor senses UV-B by tryptophan-mediated disruption of cross-dimer salt bridges.,Christie JM, Arvai AS, Baxter KJ, Heilmann M, Pratt AJ, O'Hara A, Kelly SM, Hothorn M, Smith BO, Hitomi K, Jenkins GI, Getzoff ED Science. 2012 Mar 23;335(6075):1492-6. Epub 2012 Feb 9. PMID:22323738<ref>PMID:22323738</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 4d9s" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22323738 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22323738}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Arath]]
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[[4d9s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9S OCA].
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[[Category: Arvai, A S]]
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[[Category: Christie, J M]]
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==Reference==
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[[Category: Getzoff, E D]]
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<ref group="xtra">PMID:022323738</ref><references group="xtra"/>
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[[Category: Hitomi, K]]
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[[Category: Arabidopsis thaliana]]
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[[Category: Pratt, A J]]
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[[Category: Arvai, A S.]]
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[[Category: Christie, J M.]]
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[[Category: Getzoff, E D.]]
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[[Category: Hitomi, K.]]
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[[Category: Pratt, A J.]]
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[[Category: Chromatin-binding protein]]
[[Category: Chromatin-binding protein]]
[[Category: Cop1]]
[[Category: Cop1]]

Revision as of 18:10, 5 August 2016

Crystal structure of Arabidopsis thaliana UVR8 (UV Resistance locus 8)

4d9s, resolution 1.70Å

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