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==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate==
==Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate==
<StructureSection load='4kpe' size='340' side='right' caption='[[4kpe]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
<StructureSection load='4kpe' size='340' side='right' caption='[[4kpe]], [[Resolution|resolution]] 3.43&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpf|4kpf]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3foe|3foe]], [[3fof|3fof]], [[2nov|2nov]], [[3k9f|3k9f]], [[3ksa|3ksa]], [[3ksb|3ksb]], [[3ltn|3ltn]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[4koe|4koe]], [[4kpf|4kpf]]</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [http://www.ebi.ac.uk/pdbsum/4kpe PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kpe OCA], [http://pdbe.org/4kpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kpe RCSB], [http://www.ebi.ac.uk/pdbsum/4kpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kpe ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
[[http://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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==See Also==
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*[[Topoisomerase|Topoisomerase]]
== References ==
== References ==
<references/>
<references/>

Revision as of 18:53, 5 August 2016

Novel fluoroquinolones in complex with topoisomerase IV from S. pneumoniae and E-site G-gate

4kpe, resolution 3.43Å

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