3nmx
From Proteopedia
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==Crystal structure of APC complexed with Asef== | ==Crystal structure of APC complexed with Asef== | ||
<StructureSection load='3nmx' size='340' side='right' caption='[[3nmx]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='3nmx' size='340' side='right' caption='[[3nmx]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nmx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3nmx]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NMX FirstGlance]. <br> |
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nmw|3nmw]], [[3nmz|3nmz]]</td></tr> | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nmw|3nmw]], [[3nmz|3nmz]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nmx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nmx RCSB], [http://www.ebi.ac.uk/pdbsum/3nmx PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nmx OCA], [http://pdbe.org/3nmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nmx RCSB], [http://www.ebi.ac.uk/pdbsum/3nmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nmx ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/ARHG4_HUMAN ARHG4_HUMAN]] Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.<ref>PMID:10947987</ref> <ref>PMID:12598901</ref> <ref>PMID:17145773</ref> <ref>PMID:17599059</ref> <ref>PMID:19893577</ref> | [[http://www.uniprot.org/uniprot/ARHG4_HUMAN ARHG4_HUMAN]] Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.<ref>PMID:10947987</ref> <ref>PMID:12598901</ref> <ref>PMID:17145773</ref> <ref>PMID:17599059</ref> <ref>PMID:19893577</ref> | ||
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| + | ==See Also== | ||
| + | *[[Rho guanine nucleotide exchange factor|Rho guanine nucleotide exchange factor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Chen, L]] | [[Category: Chen, L]] | ||
[[Category: Gao, L]] | [[Category: Gao, L]] | ||
Revision as of 20:30, 5 August 2016
Crystal structure of APC complexed with Asef
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