1n0w
From Proteopedia
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|PDB= 1n0w |SIZE=350|CAPTION= <scene name='initialview01'>1n0w</scene>, resolution 1.70Å | |PDB= 1n0w |SIZE=350|CAPTION= <scene name='initialview01'>1n0w</scene>, resolution 1.70Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= RAD51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BRCA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= RAD51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), BRCA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n0w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n0w OCA], [http://www.ebi.ac.uk/pdbsum/1n0w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n0w RCSB]</span> | ||
}} | }} | ||
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==Disease== | ==Disease== | ||
| - | Known | + | Known disease associated with this structure: Breast cancer 2, early onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Fanconi anemia, complementation group D1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Prostate cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Wilms tumor OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]], Breast cancer, male, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185 600185]] |
==About this Structure== | ==About this Structure== | ||
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[[Category: Venkitaraman, A R.]] | [[Category: Venkitaraman, A R.]] | ||
[[Category: Yu, D S.]] | [[Category: Yu, D S.]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: EDO]] | ||
| - | [[Category: MG]] | ||
[[Category: breast cancer susceptibility]] | [[Category: breast cancer susceptibility]] | ||
[[Category: dna repair]] | [[Category: dna repair]] | ||
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[[Category: reca-like atpase]] | [[Category: reca-like atpase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:23:46 2008'' |
Revision as of 19:23, 30 March 2008
| |||||||
| , resolution 1.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Gene: | RAD51 (Homo sapiens), BRCA2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a RAD51-BRCA2 BRC repeat complex
Contents |
Overview
The breast cancer susceptibility protein BRCA2 controls the function of RAD51, a recombinase enzyme, in pathways for DNA repair by homologous recombination. We report here the structure of a complex between an evolutionarily conserved sequence in BRCA2 (the BRC repeat) and the RecA-homology domain of RAD51. The BRC repeat mimics a motif in RAD51 that serves as an interface for oligomerization between individual RAD51 monomers, thus enabling BRCA2 to control the assembly of the RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. The RAD51 oligomerization motif is highly conserved among RecA-like recombinases, highlighting a common evolutionary origin for the mechanism of nucleoprotein filament formation, mirrored in the BRC repeat. Cancer-associated mutations that affect the BRC repeat disrupt its predicted interaction with RAD51, yielding structural insight into mechanisms for cancer susceptibility.
Disease
Known disease associated with this structure: Breast cancer 2, early onset OMIM:[600185], Fanconi anemia, complementation group D1 OMIM:[600185], Pancreatic cancer OMIM:[600185], Prostate cancer OMIM:[600185], Wilms tumor OMIM:[600185], Breast cancer, male, susceptibility to OMIM:[600185]
About this Structure
1N0W is a Protein complex structure of sequences from [1] and Homo sapiens. Full crystallographic information is available from OCA.
Reference
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex., Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell TL, Venkitaraman AR, Nature. 2002 Nov 21;420(6913):287-93. Epub 2002 Nov 10. PMID:12442171 [[Category: ]]
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