1n1l

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|PDB= 1n1l |SIZE=350|CAPTION= <scene name='initialview01'>1n1l</scene>, resolution 2.60&Aring;
|PDB= 1n1l |SIZE=350|CAPTION= <scene name='initialview01'>1n1l</scene>, resolution 2.60&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=TRL:{1-[2-(1-FORMYL-PROPYL)-3-METHANESULFONYLAMINO-PYRROLIDINE-1-CARBONYL]-2-METHYL-PROPYL}-CARBAMIC ACID TERT-BUTYL ESTER'>TRL</scene>
+
|LIGAND= <scene name='pdbligand=TRL:{1-[2-(1-FORMYL-PROPYL)-3-METHANESULFONYLAMINO-PYRROLIDINE-1-CARBONYL]-2-METHYL-PROPYL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>TRL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= H STRAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
|GENE= H STRAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
 +
|DOMAIN=
 +
|RELATEDENTRY=
 +
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n1l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n1l OCA], [http://www.ebi.ac.uk/pdbsum/1n1l PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n1l RCSB]</span>
}}
}}
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[[Category: Slater, M J.]]
[[Category: Slater, M J.]]
[[Category: Somers, D O.N.]]
[[Category: Somers, D O.N.]]
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[[Category: TRL]]
 
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[[Category: ZN]]
 
[[Category: cofactor peptide]]
[[Category: cofactor peptide]]
[[Category: helicase]]
[[Category: helicase]]
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[[Category: viral protein]]
[[Category: viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:50:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:12 2008''

Revision as of 19:24, 30 March 2008

Image:1n1l.jpg


PDB ID 1n1l

Drag the structure with the mouse to rotate
, resolution 2.60Å
Ligands: ,
Gene: H STRAIN (Hepatitis C virus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)


Overview

[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.

About this Structure

1N1L is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents., Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO, Org Lett. 2002 Dec 12;4(25):4479-82. PMID:12465917

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