3ki0
From Proteopedia
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==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-D== | ==Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-D== | ||
<StructureSection load='3ki0' size='340' side='right' caption='[[3ki0]], [[Resolution|resolution]] 1.29Å' scene=''> | <StructureSection load='3ki0' size='340' side='right' caption='[[3ki0]], [[Resolution|resolution]] 1.29Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3ki0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3ki0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillo_virgola_del_koch"_trevisan_1884 "bacillo virgola del koch" trevisan 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KI0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KI0 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G9D:3-(MORPHOLIN-4-YLMETHYL)-1,5-DIHYDRO-6H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-6-ONE'>G9D</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=G9D:3-(MORPHOLIN-4-YLMETHYL)-1,5-DIHYDRO-6H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-6-ONE'>G9D</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ess|3ess]], [[2q6m|2q6m]], [[2q5t|2q5t]], [[3ki1|3ki1]], [[3ki2|3ki2]], [[3ki3|3ki3]], [[3ki4|3ki4]], [[3ki5|3ki5]], [[3ki6|3ki6]], [[3ki7|3ki7]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ess|3ess]], [[2q6m|2q6m]], [[2q5t|2q5t]], [[3ki1|3ki1]], [[3ki2|3ki2]], [[3ki3|3ki3]], [[3ki4|3ki4]], [[3ki5|3ki5]], [[3ki6|3ki6]], [[3ki7|3ki7]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">chxa, toxA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=666 "Bacillo virgola del Koch" Trevisan 1884])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)--diphthamide_ADP-ribosyltransferase NAD(+)--diphthamide ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.36 2.4.2.36] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ki0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ki0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ki0 OCA], [http://pdbe.org/3ki0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ki0 RCSB], [http://www.ebi.ac.uk/pdbsum/3ki0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ki0 ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CHXA_VIBCL CHXA_VIBCL]] An NAD-dependent ADP-ribosyltransferase (ADPRT), it catalyzes the transfer of the ADP-ribosyl moiety of oxidized NAD onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. It probably uses the eukaryotic prolow-density lipoprotein receptor-related protein 1 (LRP1) to enter mouse cells, although there seems to be at least one other receptor as well. Is active against mouse fibroblasts, Chinese hamster ovary eEF-2, brine shrimp (Artemia spp. nauplii) and upon expression in S.cerevisiae.<ref>PMID:18276581</ref> <ref>PMID:19793133</ref> | ||
==See Also== | ==See Also== | ||
*[[Exotoxin|Exotoxin]] | *[[Exotoxin|Exotoxin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Bacillo virgola del koch trevisan 1884]] |
[[Category: Edwards, P R]] | [[Category: Edwards, P R]] | ||
[[Category: Jorgensen, R]] | [[Category: Jorgensen, R]] | ||
Revision as of 21:29, 5 August 2016
Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-D
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