1n38
From Proteopedia
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|PDB= 1n38 |SIZE=350|CAPTION= <scene name='initialview01'>1n38</scene>, resolution 2.8Å | |PDB= 1n38 |SIZE=350|CAPTION= <scene name='initialview01'>1n38</scene>, resolution 2.8Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=CH1:3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE'>CH1</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=U3H:3'-DEOXY-URIDINE+5'-TRIPHOSPHATE'>U3H</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3]) | |GENE= L1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10886 Mammalian orthoreovirus 3]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1muk|1MUK]], [[1mwh|1MWH]], [[1n1h|1N1H]], [[1n35|1N35]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n38 OCA], [http://www.ebi.ac.uk/pdbsum/1n38 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n38 RCSB]</span> | ||
}} | }} | ||
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[[Category: Nibert, M L.]] | [[Category: Nibert, M L.]] | ||
[[Category: Tao, Y.]] | [[Category: Tao, Y.]] | ||
| - | [[Category: CH1]] | ||
| - | [[Category: MN]] | ||
| - | [[Category: U3H]] | ||
[[Category: bracelet]] | [[Category: bracelet]] | ||
[[Category: right hand configuration]] | [[Category: right hand configuration]] | ||
[[Category: rna polymerase]] | [[Category: rna polymerase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:46 2008'' |
Revision as of 19:24, 30 March 2008
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| , resolution 2.8Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Gene: | L1 (Mammalian orthoreovirus 3) | ||||||
| Related: | 1MUK, 1MWH, 1N1H, 1N35
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
reovirus polymerase lambda3 elongation complex with one phosphodiester bond formed
Overview
The reovirus polymerase and those of other dsRNA viruses function within the confines of a protein capsid to transcribe the tightly packed dsRNA genome segments. The crystal structure of the reovirus polymerase, lambda3, determined at 2.5 A resolution, shows a fingers-palm-thumb core, similar to those of other viral polymerases, surrounded by major N- and C-terminal elaborations, which create a cage-like structure, with four channels leading to the catalytic site. This "caged" polymerase has allowed us to visualize the results of several rounds of RNA polymerization directly in the crystals. A 5' cap binding site on the surface of lambda3 suggests a template retention mechanism by which attachment of the 5' end of the plus-sense strand facilitates insertion of the 3' end of the minus-sense strand into the template channel.
About this Structure
1N38 is a Single protein structure of sequence from Mammalian orthoreovirus 3. Full crystallographic information is available from OCA.
Reference
RNA synthesis in a cage--structural studies of reovirus polymerase lambda3., Tao Y, Farsetta DL, Nibert ML, Harrison SC, Cell. 2002 Nov 27;111(5):733-45. PMID:12464184
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