1n3h
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= Shc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= Shc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1shc|1SHC]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3h OCA], [http://www.ebi.ac.uk/pdbsum/1n3h PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n3h RCSB]</span> | ||
}} | }} | ||
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[[Category: free protein]] | [[Category: free protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:49 2008'' |
Revision as of 19:24, 30 March 2008
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| Gene: | Shc (Homo sapiens) | ||||||
| Related: | 1SHC
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc
Overview
The notion that certain proteins lack intrinsic globular structure under physiological conditions and that the attainment of fully folded structure only occurs upon the binding of target molecules has been recently gaining popularity. We report here the solution structure of the PTB domain of the signaling protein Shc in the free form. Comparison of this structure with that of the complex form, obtained previously with a phosphopeptide ligand, reveals that the Shc PTB domain is structurally disordered in the free form, particularly around the regions constituting the peptide binding pocket. The binding of the ligand appears to reorganize this pocket through local folding events triggering a conformational switch between the free and the complex forms.
About this Structure
1N3H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Coupling of folding and binding in the PTB domain of the signaling protein Shc., Farooq A, Zeng L, Yan KS, Ravichandran KS, Zhou MM, Structure. 2003 Aug;11(8):905-13. PMID:12906822
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